Im hoping for a much more robust update to the game besides the new packs. There was talk about a single player campaign way back prior to launch. Bosses being added (I think Neoxian bought one of the boss slots).
Unless new things are added that move the game away from simply being a browser draft card game, i can see it slowly losing appeal.

"however, we can never fully predict what types of card combinations our thousands of very creative players will come up with."

The problem isnt in the Card combinations and it never was due to the rule set change each game.
The problem is when you have cards that are an easy go to for the majority of rule sets like Arianthus or Ruler of the seas. Those kinds of cards break the game and take away from the complexity of the game.
They reduce the skill level and make the game boring to play.