Brackets are simple, pick the team that you think will win, and move them to the next bracket. Picking the winning team is the not so simple part. This is what Google says are the odds. So small, in fact, that many mathematicians differ on the actual estimation of the odds. Some believe it's as low as 1 in 9,223,372,036,854,775,808 (or 1 in 9.2 quintillion, for those who skipped the last 18 digits), while others, including Jeff Bergen, a professor at DePaul, think it's as "high" as 1 in 128 billion.
In fact Warren Buffet actually put a Billion dollar challenge out there to anyone who picked a perfect bracket and that guy does not throw money around.
But in all honesty I am a sucker for my home state teams, and this year I thought U of A was going all the way. Takes the stress out of it for me when they lose in the first round, and are the biggest upset of opening day. So the take aways, if you want to win, don't pick emotionally, and don't follow my bracket. My wife and I have a bet, and she is already trying to cash that check on me.