The leader and current champion, Juventus, who travels on Saturday to the neighboring Torino court in the Turin derby, will be pressed by an Inter Milan (2nd) that will be measured hours earlier to Bologna on the eleventh date of the Series TO.
After winning 2-1 at Brescia on the intersemanal date, the 'Nerazzurri', at a point in Juve, could provisionally regain the leadership of the table, before being measured on Tuesday with Borussia Dortmund in the Champions League.
"We have played our fourth game (in Brescia) in nine days, with the same players. Now we have to recover because we are only halfway," said interim coach Antonio Conte.
The 'Vecchia Signora' had to sweat on Wednesday to save his first place against Genoa (2-1) thanks to a penalty goal by Cristiano Ronaldo in extra time when Juve played with one less man.
Torino, meanwhile, fell 4-0 against Lazio with a double from Ciro Immobile, the top scorer of the championship with 12 goals.
The coach of the Torino, Walter Mazzari, maintains the confidence of its president despite the 13th position they occupy, but the statistics of the derby of the capital of Piedmont are not favorable: since 1995 the Torino only defeated his historic rival on one occasion .
And during that period the Bianconeri have conquered 12 'Scudettos' and a Champions League, for a single title in the Serie B of the Torino.
Atalanta, third in the table, led by Colombian scorer Luis Muriel (8 goals), will receive one of the most fit teams on Sunday at Cagliari.
And the Milan that won by the minimum on Thursday at the Spal in San Siro, faces a new challenge against Lazio.
Finally, Naples, which gave two points on Wednesday at home against Atalanta, will live another complicated duel in the capital against Roma (4th), launched after knocking 4-0 on Wednesday at Udinese.