The England striker was pulled out of Tottenham's 4-1 win over Bournemouth.
Kane collided with Asmir Begovic on 34 minutes and, in the process, appeared to trap his right ankle in the turf as he tangled with the Bournemouth goalkeeper.
The striker received treatment, limped off the pitch, tried to play on but simply could not and instead headed down the tunnel, throwing a water bottle to the ground in frustration.
That reaction suggested Kane suspected it’s a bad one. History does not bode well for the 24-year-old: he was out of action for two spells last season due to ankle injuries.
Even if this one is not as severe, Kane could well miss his side’s trip to Chelsea on 1 April, which could prove pivotal to Tottenham’s hopes of a top-four finish.
A huge blow to Spurs, England and Fantasy Premier League managers who had him as captain this gameweek.