AC Milan, Atlante and Lazio are looking to win their first round of European league matches to continue on Thursday, while Germany's teams are looking for the first victory.
AC Milan host Rijeka after starting his fourth group win by beating Austrian Red Bull Salzburg 5-1.
Atalanta, who have won the first match against Everton 3-0, are in Group 5, while Lazio, who beat 11th-placed Vitesse Arnhem (3-2), will meet Belgium's Zolt Werger.
Although Rijeka is not a major threat, AC Milan are expected to be very cautious, especially with two defeats in their last three Serie A matches, despite the strong start they have made locally and in Europe.
Vincenzo Montella, the Milan coach, called for a quick move from his young side to restore balance through the Rijeka match and the next match against Roma in the Serie A.
"The administration, me and my assistant and the players, agree on the need to build a winning mentality, we have to do it quickly," Montella said.
Montilla said he would probably make changes to the squad, as in Gian Piero Gasperini's Atlanta, which is preparing for a difficult task: Lyon will meet and then beat Italy's Juventus.
"Let's think about the Lyon game, which will not be a picnic," said Gasperini, who warned his players about the Juventus game and asked them to focus on the European league's first-team adventure for the first time in 26 years.
Lazio coach Simone Inzaghi may decide to let striker Chiro Emubili, who has scored 11 goals, rest in Lazio and the Belgian will be buried tomorrow in Rome.