New blues manager, Frank Lampard, is likely to make a late decision on french international N’Golo Kante before the game begins at Old Trafford.
The French midfielder hopes to return following a knee injury while Brazilian forward Willian and Defender Antonio Rudiger (both knee) also face fitness tests but are unlikely to feature.
Christian Pulisic could make his Blues debut, following his £58million move from Borussia Dortmund.
But England duo, Ruben Loftus-Cheek and Callum Hudson-Odoi (both Achilles) will be unavailable.
Paul Pogba is fit to start Manchester United's Premier League opener against Chelsea.
The French midfielder missed the final pre-season game against the italian side AC Milan due to a back pain, but Ole Gunnar Solskjaer has confirmed he is fit for Sunday clash against the west london side Chelsea.
Harry Maguire the newly signed Manchester United player, Aaron Wan-Bissaka and Daniel James could make their debuts today against the west london side, while 17-year-old Mason Greenwood is set to be named in the squad. Eric Bailly and Tim Fosu-Mensah are still injured, while Alexis Sanchez may not be involved after picking up a hamstring issue towards the end of the just conlcuded Copa America.
Provisional squads
Man Utd: De Gea, Romero, Dalot, Wan-Bissaka, Young, Jones, Maguire, Lindelof, Rojo, Smalling, Tuanzebe, Shaw, Darmian, Chong, Garner, Gomes, James, Fred, Lingard, Matic, Mata, McTominay, Pereira, Pogba, Greenwood, Lukaku, Martial, Rashford
Chelsea: Arrizabalaga, Caballero, Azpilicueta, Zappacosta, Rudiger, Tomori, Christensen, Zouma, Alonso, Palmieri, Jorginho, Kante, Barkley, Kovacic, Mount, Kenedy, Pedro, Willian, Pulisic, Giroud, Abraham, Batshuayi.
Predicted lineups from both teams;
MANCHESTER UNITED X1 ;
De Gea, Wan-Bissaka, Maguire, Lindelof, Shaw, Matic, McTominay, Pogba, Mata, Martial, Rashford.
CHELSEAFC X1;
Kepa, Azpilicueta, Luiz, Christensen, Emerson, Kante, Jorginho, Pedro, Barkley, Pulisic, Abraham.
We hope that this game between the two big teams will be a game to remember.