The Bills have been stingy against the run this year, but have been getting absolutely shredded through the air. That doesn't bode well for them in a game against future HOFer Drew Brees. Meanwhile, the Saints defense has been relatively average this season, which is pretty much all they need to be in order for Brees to carry the team to victory. The Bills offense is likely to be a bit more potent with an additional week to integrate Kelvin Benjamin into their scheme, but I imagine there will be some growing pains there. This could very easily be a close game, but I think the Saints defense will get enough stops for their team to win.