The moment you begin to pray is the moment heaven will begin to respond. God steps into the affairs of men when He is invited. That is why He said to us to call on him and he will answer us...Jeremiah 33:3
Prayer brings down the hand of God in our lives and take charge over that which is beyond our ability.
The word of God says whatever we loose on earth shall be loosed in heaven and whatever bind on earth shall be bound in heaven.. Mathew 18:18
For this reason we should never remain silent or sit idle whiles the devil carry out his mischiefs. We should pray at all times for heaven backs our prayers.
Verily I say unto you, whatsoever you shall bind on earth shall be bound in heaven: and whatsoever you shall loose on earth shall be loosed in heaven Again I say unto you, That if two of you shall agree on earth concerning anything that they shall ask, it shall be done for them of my Father who is in heaven. For where two or three are gathered together in my name, there am I in the midst of them. Matthew 18:18-20
Knowing that God is always ready to hear us and do whatever we ask for should be enough reason for us to pray at all times and not give up.
Praying ceaselessly always brings down the hand of God, never give up when you pray.