Abstract: Association of А69314G polymorphism of ТNАР gene in the patient with acute coronary syndrome with the modified risk factors

  First name and surname: Onwughara Prince Obinna
University: Sumy State University
City: Sumy
Country: Ukraine
Faculty: Medicine
E-mail: princeo2013@yahoo.com
Presenting author: Obinna Prince Onwughara
Title: Dr
Session: Cardiology and Cardiosurgery
Type: Orginal research
Abstract: Association of А69314G polymorphism of ТNАР gene in the patient with acute coronary syndrome with the modified risk factors
 

                                                       Introduction 

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Aim. To conduct the analysis of the connection of А69314G of the gene polymorphism ТNАР in the sick people with ACS with some modified risk factors.
Materials and methods. The dark blood of the 118 sick people with ACS and of 110 almost healthy people was used. Distinguishing of the А69314G polymorphism was conducted with the help of the method of polymerase chain reaction with the further analysis of the restriction fragments’ length.
Results of the research. In the patients with the body mass index (BMI) < 25 kg/m2 the connection between the various genotypes according to the А69314G polymorphism and development of ACS (χ2=0.027; P=0.869) was not revealed. In the individuals with BMI ≥ 25 kg/м2group of control the frequency of the genotypes (А/А, А/G+G/G) comprised 85.9 and 14.1% and in the patients with ACS – 68.0 і 32.0% (χ2=7.558; P=0.006).
In homozygotes with the A/A main allele there is no connection between the size of the BMI and development of ACS (χ2=1.413; P=0.235). The number of patients with A/G + G/G genotype and the BMI < 25 and the BMI ≥ 25 kg/m2 in control group was 38.9 and 61.1% and number of patient with ACS – 13.9 and 86.1% (χ2=4.339; P=0.037).
During the analysis of the influence of the allele variants with А69314G polymorphism on the BMI, depending on the stage of obesity in the patients with ACS the authentic statistical significance was not revealed (χ2=2.467, Р=0.481).
In those, who do not smoke, there is no connection of the examined polymorphism with the development of ACS (χ2=1.831; P=0.176). Among the smokers the frequency of genotypes А/А and А/G+G/G in the control group comprised 86.2 and 13.8% and among the patients with ACS – 64.8 and 35.2% (χ2=4.310; P=0.038). Among the individuals with A/A genotype the correlation of the smokers and non-smokers in the control group comprised 72.8 and 27.2%, and in the patients with ACS – 57.3 and 42.7% (χ2=4.616; P=0.032). In the patients with А/G+G/G genotype those who smoke and those who do not smoke in the control group there were 77.8 and 22.2%, and among the patients with ACS – 47.2 and 52.8% (χ2=4.582; P=0.032).
Conclusion. In the patients with the BMI ≥ 25 kg/m2 there is connection of А69314G polymorphism of TNAP gene with the development of ACS. ACS risk in the patients with А/G+G/G genotype is higher than with А/А genotype. In the smokers with А/G+G/G genotype the risk of ACS is higher than in the individuals with A/A genotype.