I cant remember if Nitric Oxide has more binding affinity to a hemoglobin molecule than oxygen. I believe it does something funky to a bound oxygen/ hemoglobin. I believe NO can work as an antioxidant, removing superoxidants producing peroxynitrites. And if not enough endothelium produced NO can lead to peroxide formation so its amount must be in homeostasis. In this way it eases oxygen transport, too. Sorry, I dont know too much else. Im unsure how NO effects immunity.

thanks for the COX info, btw. I love your post and will follow in the future!