𝐓𝐡𝐞 𝐔𝐊 𝐰𝐨𝐮𝐥𝐝 𝐫𝐞𝐬𝐩𝐨𝐧𝐝 "𝐫𝐨𝐛𝐮𝐬𝐭𝐥𝐲" 𝐭𝐨 𝐚𝐧𝐲 𝐞𝐯𝐢𝐝𝐞𝐧𝐜𝐞 𝐨𝐟 𝐑𝐮𝐬𝐬𝐢𝐚𝐧 𝐢𝐧𝐯𝐨𝐥𝐯𝐞𝐦𝐞𝐧𝐭 𝐢𝐧 𝐭𝐡𝐞 𝐜𝐨𝐥𝐥𝐚𝐩𝐬𝐞 𝐨𝐟 𝐟𝐨𝐫𝐦𝐞𝐫 𝐬𝐩𝐲 𝐒𝐞𝐫𝐠𝐞𝐢 𝐒𝐤𝐫𝐢𝐩𝐚𝐥, 𝐁𝐨𝐫𝐢𝐬 𝐉𝐨𝐡𝐧𝐬𝐨𝐧 𝐡𝐚𝐬 𝐬𝐚𝐢𝐝.
Mr Skripal, 66, and his daughter Yulia, in her 30s, are critically ill in hospital after being found unconscious in Salisbury, Wiltshire.
The foreign secretary said he was not pointing fingers at this stage, but described Russia as "a malign and disruptive force".
Russia has denied any involvement.
Counter Terrorism Police have taken over the investigation from Wiltshire Police.
But in a statement, the unit said the inquiry had not been declared a terrorist incident and there was no risk to the wider public.
Mr Skripal - a former Russian agent convicted of spying for Britain - and his daughter were found slumped on a bench outside a shopping centre on Sunday afternoon.
Earlier they were seen walking through an alley leading from a Zizzi restaurant, which has now been "secured" by police. The Bishop's Mill pub has also been cordoned off "as a precaution".
𝐇𝐨𝐰 𝐝𝐨 𝐲𝐨𝐮 𝐭𝐞𝐥𝐥 𝐰𝐡𝐞𝐭𝐡𝐞𝐫 𝐞𝐱-𝐬𝐩𝐲 𝐰𝐚𝐬 𝐩𝐨𝐢𝐬𝐨𝐧𝐞𝐝?
Scientists at Porton Down - the UK's secret weapons research facility in Wiltshire - are studying the "unknown substance" that is thought to have made the pair ill.
Mr Johnson told MPs: "Honourable members will note the echoes of the death of Alexander Litvinenko in 2006.
"And while it would be wrong to prejudge the investigation, I can reassure the House that should evidence emerge that implies state responsibility, then Her Majesty's Government will respond appropriately and robustly...
"I say to governments around the world that no attempt to take innocent life on UK soil will go unsanctioned or unpunished."
Mr Johnson said that if it emerged Russia was linked to the incident in Salisbury "it would be very difficult to imagine" that UK representation at this summer's football World Cup could go ahead in the "normal way".
The Football Association said it believed this was in reference to a UK government presence in Russia during the tournament and not in relation to the England football team.