Recently, Canadian researchers found that running can trigger the production of VGF molecules, which can repair some brain damage in animal models. David J. Picketts, a senior scientist at Ottawa hospital and Ottawa University, said: "obviously, VGF plays an important role in the healing of brain damaged areas. We need more research to determine whether it can help in the treatment of multiple sclerosis and other neurodegenerative diseases. "
This molecule, called VGF nerve growth factor, can cure the "protective coating" problem of wrapping and isolating nerve fibers. The study was published in cell - communication. The result may have paved the way for the study of new treatments for some neurodegenerative diseases.
The researchers made a small mouse model of the cerebellum. The cerebellum is an important region of the brain responsible for balance and coordination. These defects are difficult to keep in balance and have a shorter life span, only 25 to 40 days. After that, they installed wheels on the cages of some mice so that they could run.
In the study of mouse brain, the researchers found that running in the mouse cerebellar neurons myelin increased. Myelin is a white fat like material, and the cable insulation layer is similar. Without it, neurons will not be able to spread information quickly and efficiently.
Through further research, the researchers found that VGF played a role here. It has an antidepressant effect and can make exercise enjoyable. They used the virus to introduce VGF protein into the blood of mice that did not run. The results showed that the response of mice was similar to that of running.
Surprisingly, the mice who had a chance to run were more than 12 months of life (this is a relatively normal mouse life). In addition to life lengthening, running mice would have more weight and a stronger sense of balance than the less active mice. However, once the running wheel is removed, the symptoms will return and the life span will be shortened.