According to Google Maps, the busiest time to hit the road for Thanksgiving travel is the Wednesday before Thanksgiving Day. And the busiest time is around 3 to 4 p.m., Travel and Leisure adds. That said, Google suggests either leaving earlier in the day or waiting until around 6 a.m. Thanksgiving morning to depart.
Read more here: https://www.foxnews.com/travel/traveling-for-thanksgiving-this-is-the-worst-time-to-leave