The San Antonio de Padua Church in Clarines is an icon of colonial religious architecture in Venezuela. This beautiful and peculiar temple with a cruciform plan and baroque style is located on a hill in the central town of Clarines, Diocese of Barcelona in the Anzoátegui state; It was built between 1752 and 1789 at the request of the Franciscan friar Manuel Jiménez Pérez, bishop of Puerto Rico, who installed a mission in the town.
The San Antonio de Padua Church in Clarines stands on a cross-shaped ground plan, with a single nave that ends in the presbytery, preceded by two side chapels or arms. The transept is demarcated with four semicircular arches that support a wooden dome. The general roof is vaulted over the armor.