When the patient takes the drug for the first time, the body produces the antibodies because it is believed to be harmful, dangerous to the body, and thus adheres to the mast cells, which are known as large cells, and the shape of spherical, and is important beside the immune system as it contains cytoplasmic granules, , Heparin, and serotonin.
The work of the cells is similar to the work of the alarm system, which warns the body. When the patient takes the medicine again, there is a battle between the antibodies and the components of the drug that produces the symptoms of allergies on the patient's body.