- Venusaur is exactly the same size as another Grass-type Pokémon, Tropius. Both have a height of 6'7" (2.0 m) and a weight of 220.5 lbs. (100.0 kg).
- Venusaur's number in the National Pokédex and the Fiore Browser are the same: 003.
- Due to the censor that prevents Pokémon with offensive nicknames being traded on the GTS, a Venusaur with an English name cannot be traded on the GTS without a nickname in Generation V.
- Venusaur shares its category with Bulbasaur, Ivysaur, and Sunkern. They are all known as the Seed Pokémon.
- Mega Venusaur has the highest base stat total of all Poison-type Pokémon.
- If the player chooses Charmander as their starter in Pokémon Red, Blue, FireRed, or LeafGreen, it is impossible to get Venusaur registered in the Pokédex without trading, as no NPC in the said games uses a Venusaur under this condition.
- However, in Pokémon FireRed and LeafGreen, after the player has unlocked the National Pokédex, Cooltrainer Albert uses a Venusaur in Knockout Mode at the Trainer Tower.