By: Alila Medical Media
This informative video presents a thorough examination on the nature and influence of histamine and antihistamines within the human body. Histamine's roles are explored; pertinent as a mediator of allergic reactions and equally significant in other physiological processes such as immune response, gastric acid secretion, sleep and wake cycle, cognitive ability and food intake. The video highlights the places where histamine is most prevalent and explains its storage and function in the body. Ultimately, the effects of antihistamines on these histamine receptors are covered in depth, providing insight into how these medications are used to treat conditions ranging from allergies to gastric acid disorders.
Mast cells, sensitization, and allergens are also explained and how allergic reactions occur upon repeated allergen exposure. The review further explains systemic histamine release and the potential for life-threatening anaphylaxis. A comparison between the first and second-generation antihistamines are analyzed, summarizing their structure, different binding sites, and their potential side effects due to their ability to cross or not cross the blood-brain barrier.
#Histamine #Antihistamines #Allergies #Pharmacology #Physiology