I have taken both microdoses and doses large enough, just recently in fact, to generate a literal (or at least literal feeling) out of body experience. I'd say that there are very real benefits to both but the latter is definitely not going to be anyone's cup of tea. I gave my sister her first trip with five grams and she says it was positive and transformative but that the ride was very uncomfortable for a few hours. The results with microdosing aren't nearly as dramatic but when I have taken them I do feel generally better and more at peace with the world in a very real way.

It would be interesting to know if they synergize with those other herbs. Passionflower has an maoi and will greatly increase the effects and duration of the experience. A large spoonful of raw cocoa seems to work to a lesser extent, according to the native peoples in Mexico and also in my experience but its less clear as to why. I don't think there is a ton of research on the topic so its a matter of how willing we are to test things out on ourselves. lol