I just find it interesting that our culture (that of the U.S., in my case) puts so much emphasis on ambition and never giving up, and yet sometimes--very often--clinging is actually the source of your problem.
I just gave up on something I had put a lot of passion and effort into but was just obviously not going to work, and as soon as I decided, "Alright, just let go," it felt as if every muscle in my body had received a deep-tissue massage within a timescale usually reversed for Planck lengths.
So, I guess I'm saying let's stop making a taboo out of "giving up," because damn, if the conditions are right, giving up feels completely amazing.