October 27, 2023. Potassium Can Act as an Inhibitor of the NCC Co-transporter

Article name: Dietary Potassium Stimulates Ppp1Ca-Ppp1r1a Dephosphorylation of Kidney NaCl Co-transporter and Reduces Blood Pressure

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DOI

This article was published in the Journal of Clinical Investigation in 2023. It is a study that evaluates the dephosphorylation of the NCC co-transporter mediated by potassium.

A transcriptomic screen identified Ppp1Ca, encoding PP1A, as a potassium up-regulated gene. PP1A directly binds to and dephosphorylates NCC when the extracellular potassium is elevated. We confirmed that PP1A dephosphorylates NCC directly in a potassium-regulated manner

The article shows that PP1A dephosphorylates NCC directly in a potassium-regulated manner. It has an effect similar to the one of a thiazide diuretic.

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