This article reviews the presence of P2Y receptors in the kidney. It has a section on the renal vasculature.

At the level of the smooth muscle of the afferent arteriole (AA) P2Y1 and P2Y4 receptors mediate vasoconstriction. P2X causes vasoconstriction.

At the level of the endothelium, the P2Y1 and P2Y4 receptors induce vasodilation by producing nitric oxide (NO). Endothelial P2Y2 receptor stimulation produces endothelial-derived relaxation factor, another vasodilation mediator.

P2 (purinergic receptors) are receptors for ATP.

Credits

Renal Corpuscle Image. 2019. Downloaded under a Creative Commons Attribution-Share Alike 4.0 International License from Wikimedia Commons. Author: Shypoetess. No changes were made.

Posts in this series

1. Overview

2. Overview (cont)

3. The Macula Densa Cells May Sense Tubular Salt Content Using a NHE2 Exchanger

4. The Macula Densa Cells Also Can Sense Sodium and Chloride Concentrations Using the NKCC2 Transporter

5. PGE2 Inhibits nNOS in the Macula Densa Cells

6. MAP Kinases are Activated by Low Tubular NaCl and Stimulate COX-2 Expression

7. Inhibition of nNOS in the Macula Densa leads to an Exaggerated TGF Response

8. The EP4 Receptor in the Juxtaglomerular Granular Cells Seems to be the Most Important for the Action of PGE2

9. The Juxtaglomerular Granular Cells are More Numerous in the Afferent Arteriole

10. Angiotensin II Acts on the Afferent and Efferent Arterioles, But Increases More Resistance in the Efferent Arteriole

11. Angiotensin II, Mediated by AT1 Receptors, Stimulates Nitric Oxide Release in Afferent Arterioles

12. Angiotensin II Effects are Different in the Afferent and Efferent Arterioles

13. Macula Densa Cell Depolarization Mediates Release of ATP When There is Increase in Sodium Chloride

14. The Extraglomerular Mesangial Cells Participate in the Signaling of the TGF

15. ATP is Released Through Large Channels at the Basolateral Membrane of the Macula Densa Cells

16. Ecto-5′-Nucleotidase is Present in Mesangial Cells

17. A1 Adenosine Receptors are Present in the Smooth Muscle of the Afferent Arteriole