In the Lakota tradition, they have this phrase “Wakan Tanka”, which is often translated as “Great Spirit”, meaning God or Divine Nature. However, some scholars suggest that a more literal translation is “Great Mystery”.
Many times we might face an existential crisis, some aspect of life or of ourselves which confounds us. We might even face the untimely death of a loved one. The Lakota will sometimes go to someone in such a state of grief to ask for their advice, as those people are as close to Divinity as a person can be on Earth.
When we do face those difficult questions, we might struggle with it, but perhaps we should embrace it. When we face those great confusions, we might be facing the Great Mystery.