Article name: Dietary Potassium Downregulates Angiotensin-I Converting Enzyme, Renin, and Angiotensin Converting Enzyme 2 Link DOI This article was published in the Journal of Clinical Investigation in

High Renin Hypertension High renin hypertension usually responds better to renin angiotensin aldosterone system (RAAS) blockade. #health #renin #hypertension

Low Renin Hypertension Primary hyperaldosteronism is an example of low renin hypertension #health #hypertension #renin

In patients with elevated blood pressure, the appropriate physiologic response is the suppression of renin #health #renin #hypertension

This article states that The juxtraglomerular granular has EP4 (and EP2) prostanoid receptors that respond to PGE2. There receptors are coupled to G proteins which in turn activate the adenylil cyclase

This article expresses the fact that the juxtaglomerular granular (JG) cells are present in the afferent arteriole, the efferent arteriole and the extraglomerular mesangium. However, they are much more

Primary and secondary hyperaldosteronism are conditions caused by excess aldosterone. In the primary form, renin is suppressed. In the secondary form, excess renin leads to excess aldosterone #health

Renin cleaves angiotensinogen and releases angiotensin I, the first step in the action of the renin-angiotensin-aldosterone system (RAAS)

The renin molecule! Image obtained from the public domain

The renin molecule is made of 340 amino acids and weighs 37kD

Renin is a key enzyme and hormone that helps regulates the extracellular volume and the blood pressure of an individual.

Juxtaglomerular apparatus License Creative Commons Attribution 3.0 By OpenStax College

37kDa (340 amino acids) Renin, also known as angiotensinogenase is an aspartic protease enzyme which cleaves angiotensinogen and yields the decapeptide angiotensin I. Pro-renin has also a receptor so it

This article describes the mechanisms of renin secretion, as known back in 1983. It shows that renin secretion from the juxtaglomerular cells is stimulated by decreased cytosolic calcium, which in turn