This article states that The juxtraglomerular granular has EP4 (and EP2) prostanoid receptors that respond to PGE2. There receptors are coupled to G proteins which in turn activate the adenylil cyclase which forms cAMP (second messenger). cAMP activates protein kinake A (PKA).

The activation of PKA leads to the fusion and release of renin granules (exocytosis). The mechanism may be through the activation of channels that hyperpolarize the JG cell membrane. IP receptors (PGI2) and EP2 receptors are also involved.

PGE2 also stimulates renin synthesis in JG cells via (EP) receptors through the cAMP/cAMP-responsive element-binding (CREB) pathway as shown in this article.

Credits

Renal Corpuscle Image. 2019. Downloaded under a Creative Commons Attribution-Share Alike 4.0 International License from Wikimedia Commons. Author: Shypoetess. No changes were made.

Posts in this series

1. Overview

2. Overview (cont)

3. The Macula Densa Cells May Sense Tubular Salt Content Using a NHE2 Exchanger

4. The Macula Densa Cells Also Can Sense Sodium and Chloride Concentrations Using the NKCC2 Transporter

5. PGE2 Inhibits nNOS in the Macula Densa Cells

6. MAP Kinases are Activated by Low Tubular NaCl and Stimulate COX-2 Expression

7. Inhibition of nNOS in the Macula Densa leads to an Exaggerated TGF Response

8. The EP4 Receptor in the Juxtaglomerular Granular Cells Seems to be the Most Important for the Action of PGE2

9. The Juxtaglomerular Granular Cells are More Numerous in the Afferent Arteriole

10. Angiotensin II Acts on the Afferent and Efferent Arterioles, But Increases More Resistance in the Efferent Arteriole

11. Angiotensin II, Mediated by AT1 Receptors, Stimulates Nitric Oxide Release in Afferent Arterioles

12. Angiotensin II Effects are Different in the Afferent and Efferent Arterioles

13. Macula Densa Cell Depolarization Mediates Release of ATP When There is Increase in Sodium Chloride

14. The Extraglomerular Mesangial Cells Participate in the Signaling of the TGF

15. ATP is Released Through Large Channels at the Basolateral Membrane of the Macula Densa Cells

16. Ecto-5′-Nucleotidase is Present in Mesangial Cells

17. A1 Adenosine Receptors are Present in the Smooth Muscle of the Afferent Arteriole

18. ATP Causes Vasocostriction of the Afferent Arteriole Through P2X and P2Y Receptors

19.Angiotensin II Stimulates the Na/H Exchangers of the Macula Densa Cells